“Obvious” Indications for Neural Antibody Testing in Epilepsy or Seizures: The ONES Checklist
نویسندگان
چکیده
Objective To develop a checklist that identifies patients who have “obvious” indications for neural antibody testing, and compare its diagnostic performance to predictive scores. Background Numerous scores been developed help determine which with epilepsy or seizures of unknown etiology should undergo testing. However, their advantage compared only performing testing in (e.g. broader features autoimmune encephalitis) requires further study. Design/Methods We the “Obvious” Neural Epilepsy Seizures (ONES) through literature review. then retrospectively reviewed underwent at our center between March 2019 January 2021, sensitivity specificity ONES recently-proposed Antibody Prevalence Encephalopathy (APE2)/Antibodies Contributing Focal Signs Symptoms (ACES) reflex score. Results One-hundred-seventy were identified. Seventy-four 170 (43.5%) known excluded from sensitivity/specificity analyses; none had true-positive antibody. Of 96 an etiology, fourteen (15%) The proportion false-positives was significantly higher among (3/3, 100%) (2/16, 13%) (P = .01). There no significant difference APE2/ACES score regard (93% both, P > .99) (71% versus 78%, .18) antibodies. Conclusions Compared indications, confer clear advantage. Pre-specified definitions what constitutes is required future studies avoid can confound results.
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ژورنال
عنوان ژورنال: Neurology
سال: 2022
ISSN: ['0028-3878', '1526-632X']
DOI: https://doi.org/10.1212/01.wnl.0000903136.62286.52